Mission Statement

The Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) are a collaboration of clinical researchers in 78 pediatric intensive care units across North America. These researchers have joined together to identify optimal supportive, preventive and therapeutic strategies for acute lung injury, sepsis, multi-organ failure, and other acute, life-threatening pulmonary or systemic inflammatory syndromes that affect infants and children. The PALISI Network's goal is to perform multi-center research studies to better describe disease processes and outcomes in pediatric patients and to evaluate interventions in this population. Study designs include prospective cohort studies, case-control studies, genetic epidemiology and gene expression studies, drug dosing and metabolism studies, and Phase I, II, III and IV clinical trials. PALISI network members have the ultimate goal of improving the care and health outcomes of critically ill infants and children.