Current Studies

Ongoing

  • Elaboration of a cardio-respiratory simulator (SimulRep).
  • PALIVE study: An international transversal study capturing data on how ALI patients are managed
  • A Phase III Trial of Calfactant for Acute Lung Injury in Pediatric Leukemia and Hematopoietic Stem Cell Transplant Patients (CALIPSO)
  • PediBIRN
  • NEAR-4-KIDS
  • Genetic Variation and Biomarkers in Acute Lung Injury
  • Prospective observational study of critical pertussis (in association with CPCCRN)
  • RESTORE
  • Genetic Epidemiology & Immune Response to Life Threatening Influenza in Children
  • Vaccine Effectiveness in High Risk Children
  • Phase II Pediatric RCT on Glucose Control using an electronic protocol for insulin management (HALF-PINT)
  • Brain Natriuretic Levels in Pediatric Hematopoietic Stem Cell Recipients
  • Clinical Outcomes of Children Requiring Intensive Cardiac or Pulmonary Support During Hematopoetic Stem Cell Transplant
  • Family Conferences
  • BALI
  • Transfusion and storage duration effect on monocyte and T-cell function
  • Role of RBC preservation upon immune function following transfusion
  • Incidence and outcomes for catheter related DVT
  • Immune, Coagulation, Microparticle and Microchimerism effects of RBC storage age – An Ancillary Study of the ABLE Trial
  • Implementation and Dissemination of a Blood Conservation Program
  • Analysis of packed red blood cell transfusion history in the pediatric intensive care units (PICU and PCICU) from 2000-2010
  • Development of a Transfusion Module within VPS
  • International survey on frozen plasma transfusion practices
  • DVT Prophylaxis Practice
  • PANGEA

Completed

  • A randomized clinical trial comparing two protocols (pressure support and volume support) to no protocol for weaning infants and children from mechanical ventilator support. Principal Investigator: Adrienne Randolph, MD, MSc, Children's Hospital, Boston
  • A randomized clinical trial of prone positioning for acute lung injury in children. Principal Investigator: Martha Curley, RN, PhD, Children's Hospital, Boston
  • A randomized clinical trial of calf-lung surfactant for acute lung injury. Principal Investigator: Doug Willson, MD, University of Virginia Children's Medical Center
  • An observational study of blood loss and determinants of transfusion in critically ill children, Scot Bateman, Adrienne Randolph, and Jacques Lacroix, MD
  • A randomized trial comparing a liberal versus restrictive transfusion threshold in stable critically ill children.