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​Group Designation: Working Group

Group Description

The PRone and OScillation Pediatric Clinical Trial (PROSpect) is an international clinical research study funded by the National Institutes of Health (NIH) Heart, Lung and Blood Division (NHLBI). PROSpect researchers hope to learn more about how best to care for children with acute and severe respiratory failure. The study team also hopes to learn more about a child’s quality of life and emotional health after they leave the pediatric intensive care unit. When children’s lungs are very sick they often need a machine to help them breathe (ventilator).  There are different types of breathing machines; conventional or high frequency. Children can also be placed in different positions while on a breathing machine.  The child could lie on their back (supine position) or lie on their stomach (prone position). The goal of PROSpect is to learn the best way to use breathing machines and positioning when children with very sick lungs are unable to breathe for themselves. With a parent’s permission, 1000 children from across the world will be assigned to one of four groups that combine one of the two forms of breathing machines (conventional or high frequency) and one of the two forms of positioning (supine or prone).  PROSpect includes follow-up after the child leaves the hospital. During this time, parents (or the child) will be asked to complete surveys.

Current Research

The goal of the study is to find out how best to help children on a breathing machine with a serious lung injury. We also want to learn more about how children do after they go home from the PICU (Pediatric Intensive Care Unit).


This study has two parts:

While your child is in the hospital:

Children with respiratory failure require breathing support. After you give your permission, your child will be placed in one of four groups, randomly, like rolling dice. There are different types of breathing machines and positions that can be used in children who are sick on a breathing machine. This study hopes to find out if one of two types of breathing machines and one of two different positions are better than the other in reducing the number of days children spend on breathing machines.

After your child goes home:

The rest of the study will take place for one year after your child has left the PICU. You will not have to return to the hospital for this part of the study. Instead, the study team will contact you 4 times to complete a survey that asks questions about how your child is doing.  You will be able to complete these surveys on the computer or over the phone.

After completing the 4 follow-up surveys you will receive a $50.00 debit card.  There is no cost to you to participate in this study.

See the Follow-Up Survey Info page for more information about completing the follow-up surveys.


Connect with Prospect

Contact Person: Amy Cassidy

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